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蛋白质组学组

 

万春玲

博士, 交大研究员, 研究组长, 博导
学    士 (1991-1995) 南京师范大学
硕    士 (1997-2000) 南京师范大学
博    士 (2000-2003) 中国科学院遗传与发育生物学研究所
博士后 (2003-2006) 上海交通大学
    (2010-2011) 范德堡大学
Email: clwan@sjtu.edu.cn

 

个人介绍:
        澳门拉斯维加斯线上网站行政副院长、学位委员会秘书,中国遗传学会伦理委员会委员、中国神经科学学会精神病学基础与临床分会青年委员。目前主持国家自然科学基金项目和国家重大基础研究计划项目课题。

 

研究方向

1. 代谢相关蛋白质乙酰化修饰与肿瘤发生
2. 精神分裂症分子诊断

 

代表性论文:

1. Yang J, Chen T, Sun L, Zhao Z, Qi X, Zhou K, Cao Y, Wang X, Qiu Y, Su M, Zhao A, Wang P, Yang P, Wu J, Feng G, He L, Jia W, Wan C*. Potential metabolite markers of schizophrenia. Mol Psychiatry. 2011. [Epub ahead of print]
 
2. Zhou K, Yang Y, Gao L, He G, Li W, Tang K, Ji B, Zhang M, Li Y, Yang J, Sun L, Zhang Z, Zhu H, He L, Wan C*. NMDA receptor hypofunction induces dysfunctions of energy metabolism and semaphorin signaling in rats: A synaptic proteome study. Schizophr Bull. 2010. [Epub ahead of print]
 
3. Zhang M, Huang K, Zhang Z, Ji B, Zhu H, Zhou K, Li Y, Yang J, Sun L, Wei Z, He G, Gao L, He L*, Wan C*. Proteome alterations of cortex and hippocampus tissues in mice subjected to Vitamin A depletion. J Nutr Biochem. 2011;22(11):1003-8.
 
4. Ji B, La Y, Gao L, Zhu H, Tian N, Zhang M, Yang Y, Zhao X, Tang R, Ma G, Zhou J, Meng J, Ma J, Zhang Z, Li H, Feng G, Wang Y, He L*, Wan C*. A Comparative Proteomics Analysis of Rat Mitochondria from the Cerebral Cortex and Hippocampus in Response to Antipsychotic Medications. J Proteome Res. 2009; 8(7): 3633-3641.
 
5. Ji B, Zhang Z, Zhang M, Zhu H, Zhou K, Yang J, Li Y, Sun L, Feng G, Wang Y, He L*, Wan C*. Differential expression profiling of the synaptosome proteome in a rat model of antipsychotic resistance. Brain Res. 2009; 1295:170-178.
 
6. Wan C#, Yang Y#, Li H, La Y, Zhu H, Feng G and He L*. Dysregulation of Retinoid Transporters Expression in Body Fluids in Schizophrenia Patients. J. Proteome Res. 2006; 5: 3213-3216.
 

 #并列第一作者 *通讯作者

 

 

 

青颖

博士, 上海交通大学专职科研
学    士 (2005-2009) 首都师范大学
博    士 (2010-2016) 上海交通大学
博士后 (2016-2018) 上海交通大学
Email: qingyingeva@163.com

 

个人介绍:
       上海交通大学“新进青年教师启动计划”项目主持人。关注人体微生物组及其相关代谢在精神分裂症发病中的作用,并应用多组学技术开发精神分裂症诊断及预警生物标志物。

研究方向

       精神分裂症的发病机制以及疾病分期识别生物标志物。

代表性论文:

[1] Y. Qing#, L. Sun#, C. Yang, J. Jiang, X. Yang, X. Hu, D. Cui, Y. Xu, L. He, D. Han, C. Wan*, Dysregulated 14-3-3 Family in Peripheral Blood Leukocytes of Patients with Schizophrenia, Scientific reports, 2016 Mar 31;6:23791.

[2] L. Sun#, Y. Qing#, X. Yang, C. Yang, J. Jiang, X. Hu, J. Ding, L. He, L. Tan*, C. Wan*, Gene expression profiling of the xMHC region reveals 9 candidate genes in schizophrenia, The Journal of clinical psychiatry, 2016 May;77(5):e597-9.

[3] Y. Qing, J. Yang, C. Wan*, Increased serum fibroblast growth factor 21 levels in patients with schizophrenia, The Australian and New Zealand journal of psychiatry, 2015 Sep;49(9):849-50.

[4] J. Jiang#, C. Peng#, L. Sun, J. Li, Y. Qing, X. Hu, X. Yang, Y. Li, C. Xu, J. Zhang, J. Min, X. Li, S. Qin, M. Lin, L. Tan, C. Wan*, Leukocyte Proteomic Profiling in First-Episode Schizophrenia Patients: Does Oxidative Stress Play Central Roles in the Pathophysiology Network of Schizophrenia? Antioxidants & Redox Signaling, 2019 Sep 10;31(8):579-588.

[5] C. Xu, X. Yang, L. Sun, T. Yang, C. Cai, P. Wang, J. Jiang, Y. Qing, X. Hu, D. Wang, P. Wang, G. Cui, J. Zhang, Y. Li, F. Ji, C. Liu, C. Wan*, An investigation of calcium-independent phospholipase A2 (iPLA2) and cytosolic phospholipase A2 (cPLA2) in schizophrenia, Psychiatry Research, 2019 Mar;273:782-787.

[6] J. Jiang, X. Chen, L. Sun, Y. Qing, X. Yang, X. Hu, C. Yang, T. Xu, J. Wang, P. Wang, L. He, C. Dong*, C. Wan*, Analysis of the concentrations and size distributions of cell-free DNA in schizophrenia using fluorescence correlation spectroscopy, Translational psychiatry, 2018 May 22;8(1):104.

[7] L. Sun, X. Yang, J. Jiang, X. Hu, Y. Qing, D. Wang, T. Yang, C. Yang, J. Zhang, P. Yang, P. Wang, C. Cai, J. Wang, L. He, C. Wan*, Identification of the Niacin-Blunted Subgroup of Schizophrenia Patients from Mood Disorders and Healthy Individuals in Chinese Population, Schizophrenia bulletin, 2018 Jun 6;44(4):896-907.

[8] X. Yang#, L. Sun#, A. Zhao, X. Hu, Y. Qing, J. Jiang, C. Yang, T. Xu, P. Wang, J. Liu, J. Zhang, L. He, W. Jia*, C. Wan*, Serum fatty acid patterns in patients with schizophrenia: a targeted metabonomics study, Translational psychiatry, 2017 Jul 25;7(7):e1176.

[9] C. Yang, Q. Zhou, M. Li, X. Tong, J. Sun, Y. Qing, L. Sun, X. Yang, X. Hu, J. Jiang, X. Yan, L. He, C. Wan*, Upregulation of CYP2S1 by oxaliplatin is associated with p53 status in colorectal cancer cell lines, Scientific reports, 2016 Sep 9;6:33078.

[10] C. Guo, Z. Shang, J. Yan, S. Li, G. Li, R. Liu, Y. Qing, L. Fan, H. Xiao, C. Cao*, A tunable isoelectric focusing via moving reaction boundary for two-dimensional gel electrophoresis and proteomics, Talanta, 2015 May;137:197-203.

[11] 刘莉,青颖. 从1999年-2013年“全国优秀博士论文”看我国人文社会科学博士生培养[J].清华大学教育研究,2015,36(2):14-22.

 

#并列第一作者 *通讯作者

 

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